What Does Kratom Do to Your Kidneys?

Understanding Kratom Use

Kratom, a tropical tree native to Southeast Asia, has gained popularity in recent years. People have been using kratom for various purposes, including pain relief, recreation, and self-treatment for opioid use disorder or other substance abuse disorders. Understanding the rise in kratom consumption and its legal status and regulations is essential to grasp the context of kratom use.

Rise in Kratom Consumption

Over the past two decades, the use of kratom has become more common, with an expansion of kratom vendors and increasing case reports. Estimates of the scope of kratom use in the United States vary. The availability of kratom through online platforms and retail stores has contributed to its growing popularity among individuals seeking alternative solutions for various reasons.

Legal Status and Regulations

The legal status of kratom is a complex and evolving issue. The Food and Drug Administration (FDA) has not approved kratom for any medical use, and it is not considered a controlled substance by the Drug Enforcement Administration (DEA) [1]. However, it is important to note that there may be state regulations or prohibitions against its possession and use. Therefore, it is crucial to be aware of and comply with the specific laws and regulations in your jurisdiction.

The lack of regulation surrounding kratom contributes to the spread and perceived safety of its use. The FDA has issued warnings against kratom consumption, citing various side effects, including those related to kidney and liver damage. These concerns highlight the need for further research and regulation to ensure public health and safety.

Understanding the rise in kratom consumption and its legal status and regulations allows individuals to make informed decisions regarding its use. It is essential to stay updated on evolving regulations and consult with healthcare professionals for guidance on the potential risks and benefits associated with kratom use.

Health Impacts of Kratom

As the popularity of kratom continues to rise, it is essential to understand the potential health impacts associated with its use. Kratom, a tree found in Southeast Asia, has gained attention in the United States for its opioid-like properties and effects on pain control. However, kratom use has been linked to various toxicities and adverse effects, including hyperkalemia.

Toxicity and Adverse Effects

Kratom use has been associated with a range of toxicities and adverse effects. Between 2011 and 2017, there were 1807 reports of kratom exposures in the USA, with over half resulting in serious medical outcomes [1]. Some of the reported adverse effects include withdrawals, neonatal abstinence syndrome, hypothyroidism, hypogonadism, liver toxicity, seizures, coma, and even fatalities.

While the exact mechanisms behind these toxicities are not fully understood, it is crucial to recognize the potential risks associated with kratom use. Individuals considering kratom should be aware of the potential adverse effects and consult with healthcare professionals before use.

Reported Cases of Hyperkalemia

Hyperkalemia, a condition characterized by high levels of potassium in the blood, has been reported in association with kratom use. One documented case involves a 61-year-old patient with no significant medical history. After discontinuation of kratom, the patient's potassium levels returned to normal.

It is important to note that kratom-induced hyperkalemia is a relatively rare occurrence. However, this case highlights the need for caution and monitoring when using kratom, as it can potentially affect electrolyte balance and kidney function.

These health impacts underscore the importance of understanding the potential risks and staying informed about the latest research on kratom use. As with any substance, it is crucial to weigh the potential benefits against the potential risks and make informed decisions regarding its use. Consulting with healthcare professionals can provide valuable guidance regarding the potential health impacts of kratom use.

Kidney Damage from Kratom

Kratom, a substance derived from the leaves of the Mitragyna speciosa tree, has gained popularity in recent years. However, concerns have been raised regarding its potential impact on kidney health. Understanding the signs, symptoms, and potential progression to kidney failure is essential for individuals using or considering the use of kratom.

Signs and Symptoms

Signs of kidney damage from kratom use may manifest after a period of regular consumption, often starting with liver-related symptoms. According to Steps to Recovery, individuals abusing kratom regularly may experience symptoms within 1-8 weeks of severe use. These symptoms can include:

• Bright yellow urine: The liver plays a crucial role in processing substances in the body, including metabolizing kratom. When the liver becomes compromised, it may result in bright yellow urine, indicating that the liver is unable to function properly.
• Loss of appetite: Kidney damage from kratom can lead to a decreased appetite, which may contribute to weight loss and nutritional deficiencies.
• Constipation: Kratom use has been associated with digestive issues, including constipation. This can further impact overall well-being and contribute to discomfort.
• Liver damage: Kidney damage from kratom often occurs after the liver becomes compromised. If left untreated, liver damage can worsen and lead to further complications.
• Bodily inflammation: In some cases, kidney damage from kratom can result in inflammation throughout the body, leading to discomfort and potential complications.

Progression to Kidney Failure

If kidney damage caused by kratom is left untreated, it can progress to kidney failure.egular consumption of kratom over an average period of 11 years presents suggestive signs of kidney failure. However, it's important to note that kidney failure associated with kratom often occurs after the liver becomes compromised.

Kidney failure is a serious condition that occurs when the kidneys can no longer adequately filter waste products from the blood. Without proper treatment, kidney failure can lead to a range of complications and potentially become life-threatening.

It is essential to seek medical attention if you suspect kidney damage or experience any symptoms associated with kidney dysfunction. Early detection and intervention can help prevent further damage and manage the condition effectively.

In light of the potential risks and adverse effects associated with kratom, it is crucial to consider the lack of approval and regulation by the FDA. They have issued warnings against kratom consumption due to various side effects, including those related to kidney and liver damage. Lack of regulation contributes to the spread and perceived safety of kratom [3].

Further research and understanding of the chemical compounds present in kratom are necessary to fully comprehend its effects on kidney health. It is prudent to exercise caution and prioritize one's overall well-being when considering the use of kratom or any substance that may pose potential risks to kidney health.

Connection to Liver Health

When examining the potential impact of kratom on the body, it's important to consider its connection to liver health. The liver plays a crucial role in metabolizing substances, including kratom. Prolonged and excessive use of kratom has been associated with liver damage, which can subsequently affect kidney health.

Liver Function and Kratom Use

Regular and severe use of kratom can lead to liver damage. Symptoms such as bright yellow urine, loss of appetite, constipation, and bodily inflammation may indicate liver dysfunction. The liver is responsible for processing and filtering substances, and when it becomes compromised due to kratom abuse, it can negatively impact other organs, including the kidneys.

Impact on Kidney Health

Kidney damage is more likely to occur in individuals who abuse kratom regularly. Symptoms typically emerge after approximately 1-8 weeks of severe use, often beginning with liver issues before progressing to kidney problems [3]. If left untreated, kidney failure caused by kratom can worsen over time, leading to further complications such as loss of appetite, constipation, liver damage, and inflammation.

Liver failure resulting from kratom abuse can lead to overworking of the kidneys, as the liver's inability to function properly can place an additional burden on the kidneys. This increased workload on the kidneys can eventually lead to kidney damage [3].

It's important to note that the U.S. Food and Drug Administration (FDA) has not approved kratom for use and has issued warnings against its consumption. The lack of regulation surrounding kratom contributes to its spread and perceived safety, despite the potential risks to liver and kidney health.

Understanding the connection between kratom use, liver health, and subsequent kidney damage is crucial for individuals considering or currently using kratom. Monitoring liver function and seeking medical attention if experiencing symptoms associated with liver or kidney damage is essential for maintaining overall health and well-being.

FDA Warnings and Safety Concerns

As the popularity of kratom continues to rise, concerns regarding its safety and potential adverse effects have come to the forefront. The U.S. Food and Drug Administration (FDA) has not approved kratom for any medical use and has issued warnings against its consumption, highlighting various side effects, including those related to kidney and liver damage. The lack of approval and regulation contribute to the spread and perceived safety of kratom.

Lack of Approval and Regulation

Kratom is not currently approved by the FDA for any medical use. Additionally, it is not considered a controlled substance by the Drug Enforcement Administration (DEA). However, it's important to note that state regulations or prohibitions against kratom possession and use may exist [1]. The lack of approval and regulation means that the quality, purity, and safety of kratom products on the market may vary significantly. This poses potential risks to consumers, including those related to kidney health.

Safety Issues and Risks

Several safety issues have been identified in relation to kratom use. The FDA has raised concerns about the potential adverse effects of kratom, including those affecting the kidneys and liver. While further research is needed to fully understand the risks, it is important to be aware of the potential dangers associated with kratom consumption. Adverse effects on kidney health may include toxicity and damage to renal function.

Given the lack of regulation, it is difficult to determine the exact prevalence and severity of kidney-related issues associated with kratom use. However, caution should be exercised, and individuals considering kratom consumption should be aware of the potential risks and consult with healthcare professionals.

In conclusion, the FDA has not approved kratom for any medical use and has expressed concerns about its safety, including potential adverse effects on kidney health. The lack of regulation further underscores the need for caution when considering kratom consumption. As research on kratom continues to evolve, it is essential to stay informed about its potential risks and make informed decisions regarding its use.

Research and Future Considerations

As the use of kratom continues to rise, there is a growing need for research and further understanding of its effects on the body, including its impact on kidney health. Although kratom leaves contain many chemical compounds, such as mitragynine and 7-hydroxymitragynine, the exact mechanisms by which these compounds affect the body are still not fully understood [2].

Chemical Compounds in Kratom

Kratom leaves contain a variety of chemical compounds that interact with the body. Mitragynine and 7-hydroxymitragynine are two of the key alkaloids found in kratom. These compounds have been found to partially activate mu-opioid receptors in the brain, which may contribute to their effects. However, it's important to note that the effects of kratom compounds are only partially comparable to opioids. Kratom compounds may also bind to adrenergic receptors, serotonin receptors, and dopamine receptors, potentially contributing to their stimulating effects [2].

Need for Further Study

Despite the increasing popularity of kratom and its potential therapeutic uses, there is still a lack of comprehensive research on its long-term health effects, including its impact on kidney function. Further studies are needed to assess the safety profile of kratom, especially regarding its potential adverse effects on various organs, including the kidneys.

Researchers are particularly interested in understanding how kratom use may impact individuals who are struggling with opioid addiction. The National Institute on Drug Abuse (NIDA) is actively studying the relationship between kratom and opioids, as opioid use continues to drive the drug overdose epidemic in the United States.

To fully comprehend the risks and benefits of kratom, it is essential to conduct rigorous scientific studies that investigate its chemical composition, pharmacological properties, and potential therapeutic applications. Additionally, studies should explore the long-term effects of kratom use on various organ systems, including the kidneys.

In conclusion, while kratom has gained popularity and is used for various purposes, there is still much to learn about its effects on the body, including its impact on kidney health. Ongoing research and future studies will help shed light on the potential risks and benefits of kratom use, providing a more comprehensive understanding of this substance.

References

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093675/‍

[2]: https://nida.nih.gov/research-topics/kratom

‍[3]: https://www.stepstorecovery.com/blog/what-does-kratom-do-to-your-kidneys/